The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals a lot less than six decades of age, due to the fact The mix could result in deadly respiratory depression Within this age populace.
Convey to your physician If you're pregnant or Believe you may be Expecting. Through pregnancy, this merchandise will not be recommended. It could damage an unborn toddler. Check with your medical professional in regards to the challenges and great things about this medication. See also Warning area.
Tend not to increase your dose or use this product or service extra often or for for a longer period than prescribed. Your problem is not going to increase any more quickly, plus your possibility of Unwanted side effects will boost.
That can help avoid withdrawal, your doctor may possibly reduce your dose bit by bit. Withdrawal is a lot more likely For those who have utilized this medication for years (various months) or in substantial doses. Convey to your medical professional or pharmacist without delay In case you have withdrawal.
Narcotic analgesics cause histamine launch, which appears to become chargeable for wheals or urticaria in some cases found at the website of injection on parenteral administration.
Epinephrine – Due to the potential for promethazine to reverse epinephrine’s vasopressor effect, epinephrine shouldn't be made use of to take care of hypotension affiliated with promethazine overdose.
The chance for extreme respiration issues is increased when You begin this medication, or if you are taking the incorrect dose or get much more of the medication than prescribed. Having this medication with Alcoholic beverages or other medication that could cause drowsiness or respiration troubles may lead to very serious side effects, like Dying. Also, other medications can affect the removing of this item out of your body, which can impact how it works.
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A healthcare professional need to be consulted ahead of getting any drug, switching any eating plan or commencing or discontinuing any course of remedy.
Codeine: A review in rats and rabbits noted no Promethazine codeine syrup teratogenic outcome of codeine administered over the period of organogenesis in doses ranging from five to 120 mg/kg. From the rat, doses with the 120mg/ kg level, during the toxic range to the Grownup animal, were linked to an increase in embryo resorption at time of implantation.
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Drug interactions may possibly alter how your prescription drugs operate or raise your chance for serious Uncomfortable side effects. This document isn't going to consist of all doable drug interactions.
Given that recurrences of NMS happen to be documented with phenothiazines, the reintroduction of promethazine HCl must be cautiously deemed.